Nano-coating protects biofunctional materials

Autor(en)

Rupert Tscheliessnig, Martin Zörnig, Eva M. Herzig, Katharina Lückerath, Jens Altrichter, Kristina Kemter, Adnana Paunel-Görgülü, Tim Lögters, Joachim Windolf, Silvia Pabisch, Jindrich Cinatl, Holger F. Rabenau, Alois Jungbauer, Peter Müller-Buschbaum, Martin Scholz, Joachim Koch

Abstrakt

The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (>= 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.

Organisation(en)

Dynamik Kondensierter Systeme

Externe Organisation(en)

Universität für Bodenkultur Wien, Georg-Speyer-Haus - Institute for Biomedical Research Frankfurt am Main, Technische Universität München, Leukocare AG, Heinrich-Heine-Universität Düsseldorf, Johann Wolfgang Goethe-Universität Frankfurt am Main

Journal

Materials Today

Band

15

Seiten

394-404

Anzahl der Seiten

11

ISSN

1369-7021

DOI

https://doi.org/10.1016/S1369-7021(12)70166-9

Publikationsdatum

2012

Peer-reviewed

Ja

ÖFOS 2012

103009 Festkörperphysik, 103015 Kondensierte Materie, 103018 Materialphysik

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/nanocoating-protects-biofunctional-materials(f5ae3de7-e08f-45a0-b207-50d712484f82).html