Publikationen

Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel

Autor(en)
Meder Kamalov, Hanspeter Kaehlig, Christian Rentenberger, Alexander Müllner, Herwig Peterlik, Christian F. W. Becker
Abstrakt

Here we show that the well-known ovalbumin epitope SIINFEKL that is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel. We investigate properties of this hydrogel by a range of spectroscopic and imaging techniques demonstrating that the hydrogel is stabilized by self-assembly of the peptide into nanofibres via stacking of beta-sheets. As peptide hydrogels are known to stimulate an immune response as adjuvants, the immunoactive properties of the SIINFEKL peptide may also originate from its propensity to self-assemble into a hydrogel. This finding requires a re-evaluation of this epitope in adjuvant testing.

Organisation(en)
Institut für Biologische Chemie, Institut für Organische Chemie, NMR Zentrum, Physik Nanostrukturierter Materialien, Dynamik Kondensierter Systeme
Journal
Scientific Reports
Band
9
Anzahl der Seiten
6
ISSN
2045-2322
DOI
https://doi.org/10.1038/s41598-019-39148-8
Publikationsdatum
02-2019
Peer-reviewed
Ja
ÖFOS 2012
Chemische Biologie, Biochemie
Schlagwörter
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/ovalbumin-epitope-siinfekl-selfassembles-into-a-supramolecular-hydrogel(0332a6e5-1e21-4c2b-8d22-226eac7c73a7).html