Publications
Nano-coating protects biofunctional materials
- Author(s)
- Rupert Tscheliessnig, Martin Zörnig, Eva M. Herzig, Katharina Lückerath, Jens Altrichter, Kristina Kemter, Adnana Paunel-Görgülü, Tim Lögters, Joachim Windolf, Silvia Pabisch, Jindrich Cinatl, Holger F. Rabenau, Alois Jungbauer, Peter Müller-Buschbaum, Martin Scholz, Joachim Koch
- Abstract
The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (>= 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.
- Organisation(s)
- Dynamics of Condensed Systems
- External organisation(s)
- University of Natural Resources and Life Sciences, Georg-Speyer-Haus - Institute for Biomedical Research Frankfurt am Main, Technische Universität München, Leukocare AG, Heinrich-Heine-Universität Düsseldorf, Johann Wolfgang Goethe-Universität Frankfurt am Main
- Journal
- Materials Today
- Volume
- 15
- Pages
- 394-404
- No. of pages
- 11
- ISSN
- 1369-7021
- DOI
- https://doi.org/10.1016/S1369-7021(12)70166-9
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 103009 Solid state physics, 103015 Condensed matter, 103018 Materials physics
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/f5ae3de7-e08f-45a0-b207-50d712484f82